ANTIBIOTIC RESISTANCE SURVEILLANCE OF GRAM-NEGATIVE BACTERIA: K. PNEUMONIAE, E. COLI, P. AERUGINOSA, AND A. BAUMANNII AT DA NANG C HOSPITAL

Abstract

Introduction: The prevalence of antibiotic-resistant bacteria is increasing, especially gram-negative bacteria causing high mortality rates such as Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Objective: To investigate the antimicrobial resistance of gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii. Method: A cross-sectional descriptive study was conducted, extracting data from the Whonet software at the microbiology department from September 2018 to October 2022 at Da Nang C Hospital. Results: The total number of bacterial strains isolated over 5 years is 4632, with Klebsiella pneumoniae (894 strains, 19,3%), Escherichia coli (1420 strains; 30,66%), Pseudomonas aeruginosa (707 strains; 15,26%), Acinetobacter baumannii (613 strains; 13,23%). Klebsiella pneumoniae strains showed resistance over 50%, especially ciprofloxacin with a resistance rate of 78,4% in 2022; carbapenem resistance ranged from 30 - 53%. Escherichia coli resistance to fluoroquinolone was over 70% in 2022; Pseudomonas aeruginosa carbapenem resistance was below 50%; fluoroquinolone resistance was over 40%. Acinetobacter baumannii bacterial strains showed 92,8% resistance to ceftriaxone in 2022; carbapenem, cephalosporin, aminoglycoside, and fluoroquinolone resistance rates were over 70% Conclusions: Many bacterial strains exhibit very high resistance to common antibiotics. The research findings provide a basis for monitoring rational antibiotic use to limit the increase of antibiotic-resistant bacteria.